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Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use.
Want to stay on top of the science and politics driving biotech today? Sign up to get our biotech newsletter in your inbox. Good morning! A crowdsourced Readout today, to be sure, with contributions from STAT’s Jason Mast, Elaine Chen, and Jonathan Wosen. We get into earnings from Novo Nordisk, Amgen, and Illumina, and see that ICER is not so enthused about a gene therapy from Sarepta. Also: We’d like to know what you think of this newsletter. if you haven’t, could you fill out this survey? Novo Nordisk CEO defends price of Wegovy, Ozempic Novo Nordisk CEO Lars Fruergaard Jørgensen is standing by the cost of Ozempic and Wegovy, despite an ongoing Senate investigation into the company’s pricing. In an earnings call yesterday, he said the drugs offer “an attractive value proposition” as they’re priced similarly to earlier, less effective iterations of this class of drugs. Although he conceded that the number of people taking the drugs “is to some degree putting strains on health care systems,” STAT’s Elaine Chen writes, the full value of these diabetes and obesity drugs has yet to be realized. Ozempic’s list price is $969 monthly; Wegovy’s is $1,349. Executives on the call said that the net prices for these drugs have already come down, and will continue to do so as more people take it — and as competition increases. Read more. On the ethics of live-brain research The removal of small amounts of brain tissue from desperately ill patients, done as part of a Mount Sinai research project, triggered alarm bells at the FDA and has raised broader questions about the scientific and ethical justification for live-brain research. Journalist and STAT contributor Katherine Eban joins “The Readout LOUD” this week to discuss the findings of a two-year investigation. Also on this week’s episode, STAT’s Adam Feuerstein and Allison DeAngelis discuss Novartis’ effort to acquire MorphoSys, and the latest news on Eli Lilly and Novo Nordisk’s blockbuster obesity drugs with Elaine Chen. Listen here. ICER casts doubt on Sarepta’s DMD gene therapy From STAT’s Jason Mast: The drug-pricing watchdogs over at the Institute for Clinical and Economic Review, or ICER, often take a dim view of modern drug pricing — except when it comes to gene therapy. Those treatments, the nonprofit has said, often provide the years-long benefits for severe disease that justify a multimillion-dollar price tag. Which makes the JAMA piece published this week by ICER CMO David Rind all the more notable. Rind considered Elevidys, Sarepta’s $3.2 million gene therapy for Duchenne muscular dystrophy. The treatment was given accelerated approval last year for 4- and 5-year-olds and, after a Phase 3 trial, the FDA is now considering whether to approve it for all ages. That Phase 3 trial missed its primary endpoint, though, as did a previous smaller study. Sarepta has pointed to the results on secondary measures but given those data, Rind cast doubt on whether it should be approved — and certainly whether Sarepta should charge what other gene therapy companies do. “This is an enormous price tag for a therapy that has failed to meet its primary end point in the 2 randomized trials in which it has been studied and that is clearly not curative,” he wrote. Amid a rocky year for genomics, Illumina revenue on track to stay flat From STAT’s Jonathan Wosen: DNA sequencing juggernaut Illumina reported yesterday $1.06 billion in revenue for its core business during the first quarter of this year, down 2% from the same time last year, with the company’s execs reiterating that they expect 2024 revenue to essentially match the $4.5 billion from the previous fiscal year. CEO Jacob Thaysen cautiously described the first-quarter numbers as a “decent start to the year” that exceeded expectations on a call with market analysts and investors. The updated numbers come during a turbulent time for the broader sequencing space. Pacific Biosciences, a Bay Area company that Illumina once unsuccessfully tried to acquire, recently laid off nearly 200 employees after reporting disappointing first-quarter sales. And while Illumina continues to control about 80% of the market, its shares are down 37% from a year ago and the firm faces growing competition from players such as Ultima, Singular Genomics, and Element Biosciences. The San Diego genomics giant is still on track to finalize the terms of its divestiture of Grail — a cancer detection startup Illumina had acquired for $8 billion, drawing the ire of regulators in the U.S. and Europe — by the end of the second quarter of this year. Amgen goes all in on injectable obesity drug From STAT’s Elaine Chen: Amgen will scrap an early-stage obesity pill, and will instead focus on its more advanced injectable candidate called MariTide that’s seen as a potential competitor to Wegovy and Zepbound. MariTide is in a Phase 2 trial for obesity, and CEO Bob Bradway said on the earnings call yesterday that “we are very encouraged with the results” from an interim analysis of that trial. The company is planning a “broad” Phase 3 program that will study MariTide in obesity, diabetes, and obesity-related conditions, and it’s already gearing up to make large amounts of the drug, initiating activities “to further expand manufacturing capacity with both clinical and commercial supply in mind,” Bradway said. MariTide has an interesting mechanism — it’s a monoclonal antibody linked to two peptides that activates receptors of the GLP-1 hormone while blocking receptors of the GIP hormone. Even though that appears to contradictory to the mechanism of Lilly’s potent obesity drug Zepbound, which activates both GLP-1 and GIP receptors, MariTide has shown potential to induce potent and longer-lasting weight loss. Read more. More reads Biotech vets raise $67 million to develop targeted activators for cancer, Endpoints Regeneron’s blockbuster eye drug posts weaker sales due to inventory impact, Reuters window.statGlobal = window.statGlobal || { }; window.statGlobal.analytics = window.statGlobal.analytics || { }; window.statGlobal.analytics.fbq = function( eventName, parameters ) { jQuery.ajax( { url: ‘/wp-json/stat-analytics/v1/facebook-pixel’, type: ‘POST’, data: { event_name: !eventName ? null : eventName, parameters: !parameters ? {} : parameters, source_url: window.location.href }, success: function( data, textStatus, jqXHR ) { //console.log( data ); }, error: function ( jqXHR, textStatus, errorThrown ) { //console.log( jqXHR ); } } ); }; jQuery( window ).on( ‘load’, function() { if ( !window.bgmpGdpr || window.bgmpGdpr.isOptedOut() ) { return; } !function(f,b,e,v,n,t,s){if(f.fbq)return;n=f.fbq=function(){n.callMethod? n.callMethod.apply(n,arguments):n.queue.push(arguments)};if(!f._fbq)f._fbq=n; n.push=n;n.loaded=!0;n.version=’2.0′;n.queue=[];t=b.createElement(e);t.async=!0; t.src=v;s=b.getElementsByTagName(e)[0];s.parentNode.insertBefore(t,s)}(window, document,’script’,’https://connect.facebook.net/en_US/fbevents.js’); fbq( ‘init’, ‘436331036555416’ ); fbq( ‘track’, ‘PageView’ ); document.addEventListener( ‘stat-hubspot-signup-subscribed’, () => { // Successful HubSpot newsletter signup AJAX form submission. window.statGlobal.analytics.fbq( ‘Lead’ ); } ); } ); Source link
DISCLAIMER: As a family medicine physician, I strive to provide accurate and helpful information in my videos. However, please note that the content of these videos is for informational purposes only and should not be considered medical advice. It is important to always consult with your own healthcare provider before making any changes to your health regimen. By watching these videos, you agree that I am not liable for any damages or losses that may result from the information provided.
In the ongoing Ozempic craze, one woman's alleged actions may have had dangerous effects. Isis Navarro Reyes, a TikToker and New York state resident, was arrested on May 1 for allegedly using...
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COREY Gamble has stunned fans with his drastic weight loss as he appeared much slimmer at recent NBA games.On Friday, The Kardashians star shared seve...
Sure! Here are five quick and effective weight loss tips:
1. Eat a Balanced Diet: Focus on consuming whole foods that are nutrient-dense and avoid highly processed foods. Include a variety of vegetables, fruits, lean proteins, whole grains, and healthy fats in your meals. Be mindful of portion sizes and try to reduce your consumption of sugary snacks and beverages.
2. Stay Hydrated: Drinking water can help boost your metabolism and control hunger cravings. Aim to drink at least 8 cups (64 ounces) of water per day. If you find plain water boring, try infused water with slices of fruits or herbs for added flavor.
3. Increase Physical Activity: Engage in regular exercise to burn calories and build muscle. Incorporate both cardiovascular exercises, such as jogging or cycling, and strength training exercises, like weightlifting or bodyweight exercises. Aim for at least 150 minutes of moderate-intensity aerobic activity per week, along with strength training two days a week.
4. Get Enough Sleep: Sleep is crucial for weight management. Lack of sleep can disrupt your hormonal balance, leading to increased hunger and cravings. Aim for 7-8 hours of quality sleep each night to support your weight loss efforts.
5. Practice Mindful Eating: Pay attention to your body's hunger and fullness cues. Avoid eating in front of screens or while being distracted, as it can lead to overeating. Eat slowly, savor each bite, and stop eating when you feel satisfied, but not overly full.
Remember, sustainable weight loss is a gradual process, so it's important to be patient with yourself. Consult a healthcare professional before starting any new weight loss program or making significant changes to your diet or exercise routine.
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Novo Nordisk, the Danish maker of the injectable diabetes drug Ozempic and its sister weight-loss medicine Wegovy, is planning to slash prices amid both…...
The best advice for long-term weight loss is to focus on sustainable lifestyle changes rather than quick fixes. This includes eating a balanced diet, exercising regularly, staying hydrated, getting enough sleep, managing stress, and being patient with yourself. It's not just about losing weight but about adopting healthier habits for life.
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🎧Note music in this video - NCS
Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in favor of fair use.
Danish drugmaker Novo Nordisk has eclipsed French luxury group LVMH to become Europe’s most valuable company – thanks to demand for diabetes and weight-loss drugs.
As Wegovy becomes available to Canadians starting Monday, a medical expert is cautioning patients wanting to use the drug to lose weight that no medication is a ''magic bullet,' and the new medication is meant particularly for people who meet certain criteria related to obesity and weight.
In the ongoing Ozempic craze, one woman's alleged actions may have had dangerous effects. Isis Navarro Reyes, a TikToker and New York state resident, was arrested on May 1 for allegedly using...
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Welcome to Angelic Lift's YouTube channel! Medical Weight Loss, Non-Surgical Skin Tightening/Rejuvenation, Bio-Identical Hormone Replacement, Testosterone Replacement, Menopause Treatment, Thyroid and Autoimmune Help is our specialty. We believe in non-invasive preventative natural options that help in optimizing health. Join us as we share results, useful tips and insights to achieve these goals without breaking the bank.
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* NEW VIDEOS EVERY WEEK!* I have begun a weight loss journey and I want to share it with you in hopes that my videos help someone else going through the same thing. Rybelsus (semaglutide) worked for a short time and now I have started using Mounjaro (tirzepatide). Join me as I document my experience with weekly update videos. #releasethevial
If you are new here, my husband and I just bought this new home at the end of January 2021. HI! I'm Jennifer, a "Happily Married" and I am a Mom³ to Justin (31) Jaden (15) Levi (9) but currently a stay at home momma to my two youngest boys. My middle son has Autism and ADHD so it's a struggle... Amen! Happily married to my husband Jerry (FRESH CAROLINA CATS). We live in NC and I upload NEW VIDEOS every week! I also do vlogmas, cleaning motivation, cook with me, planner videos, Grocery Hauls, Dollar Tree Hauls, Lifestyle videos, and MORE!
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